Sunday, March 16, 2008
If Viruses Reach The World Ecology, Two Solutions.
...How to Know If We'll Win The Race In Time and A Powerful New Defence Strategy Used In Health Science.....
As in our evolution with civilization it's now believed our evolution is speeding up because with more of us in history there are more combinations of genes and by retaining the genes of worth for our advantage we've adapted to many more realms, e.g. the far north of eskimos or the desert or even the urban jungle. This idea that number crunching allows higher speed evolution may be important to our future because it means with more people who have lethal viruses, the number of mutations to find more ways to adapt the viruses have may be increased like our higher speed evolution, so it's more common that deadly viruses may mutate to live in the water or air than in most of evolution. The bad news with more computing power like this it may be just a matter of time before this type of mutation is found. But there's good news too. A new mathematical formula has been devised by bioengineer Micheal Deem of Rice University for use in medicine to calculate how many times the virus must copy and mutate to overpower antiviral drugs. This may help researchers fine tune compounds early in the clinical development of new antiviral drugs. Because viruses are mostly simple, it's a simple formula to calculate, with just a few parameters found by lab research for the savvy about each virus. If the virus must copy 10, 20, or even 100 times to overpower the medicine and we're ahead of the virus in power we know the virus will lose and we'll win. "At this rate the virus won't have time to correct errors or absorb drug evading changes and it will crash." Other good news (if you're not a virus) is that new antiviral drugs being researched at many university labs use extra random DNA that's almost always lethal to the virus. This method, lethal mutagenesis is like throwing a wrench into the machinery that fools the virus into using bad DNA. Most random mutations are lethal and not harmful to other life. My addition here is the observation that the formulas may be used to calculate other problems the virus may try to solve too, like adapting to life in the water or air, so at any rate we'll know how much time we have left to solve the problem. If we're going to lose the race at least we'll know and be ready for the worst with more money for research for our best defence, and if we are going to win the marathon we'll know if the nations of the world are safe or just how much it might take to win, otherwise this may be a problem if we didn't have a way to know what's most optimal..
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